Welcome to our blog on combining relative potencies. In this blog, we’ll review the methods recommended by the United States Pharmacopeia (USP) and European Pharmacopoeia (PhEur) for combining relative... read more →
Our clients sometimes tell us that they don’t want to use response transformations since it feels like an unwarranted manipulation of the data. However, there is little point in... read more →
Many of our readers will be familiar with our paper “Parallelism in Practice” (PDA Journal of Pharmaceutical Science and Technology, 2015) and how we examined the common methods... read more →
Following the EurPh recommendations mixes up system and sample suitability and can lead to undesirable results. Assays failing when they should pass Assays passing when they should fail We... read more →
We have previously discussed the 4 parameter logistic (4PL) model. This is a symmetrical S-shaped curve with the equation \[y=D+\frac{A-D}{1+e^{B\left(\log(dose)-C\right)}}\] for a response y. Sometimes you may see slightly... read more →