Francis Bursa
Following the EurPh recommendations mixes up system and sample suitability and can lead to undesirable results.
We recommend some alternative approaches to the problem.
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Senior Statistician – Francis joined Quantics in 2013. With a Masters from Cambridge and DPhil in Theoretical Physics from Oxford University, Francis brings high level mathematical ability and extensive experience in simulation techniques to Quantics. These techniques can be used to explore “what if” scenarios, reducing the need for further experimental data. Francis heads the R&D team.
Ian Yellowlees Accuracy and Precision are properties of an experiment which are often conflated — not least because they are often synonymous in everyday conversation. In science, however, they have separate, well-defined meanings. Of course, this also applies to bioassay, so we thought we’d take a look at the difference here. Accuracy is the ability…
Brooke Franklin | Jason Segall In the first part of this series, we investigated the use of the coefficient of determination—R2—to measure goodness-of-fit. Specifically, we showed that it is an inadequate tool: a low R2 does not always mean a poor model fit; a high R2 does not always mean a good model fit; and…
Ann Yellowlees | Jason Segall Relative. Thanks for reading…But wait a moment! Have you ever stopped to ask why relative potency (RP) assays are the most common potency assay? Perhaps there are cases where absolute potency (AP) would be better? Indeed, Quantics occasionally come across clients who continue to use AP for their assays. Are…
Matthew Stephenson | Jason Segall Vaccines are among the most important technological developments in human history. From the earliest attempts to prevent smallpox by variolation to modern mRNA vaccines built without a virus needing to have entered the development lab, the vaccine has become a vital string in the bow of public health officials. As…
Ishara Fernando We have all experienced the frustration (and sometimes utter dejection!) of performing a bioassay to what you thought was near perfection only to come back, analyse the data, and find out your assay has failed goodness-of-fit. This can happen even when, visually, the data points look to be very close to the fitted…
Ann Yellowlees Interpolation analysis is used to find the concentration of a substance in a sample. For biologics, this is often used in ELISA and other bioanalytic analyses. This blog introduces interpolation analysis for ELISA and presents a new method developed by Quantics. The Bursa-Yellowlees Method uses the available ELISA data more effectively and greatly…