Author Archive for Francis Bursa

Quantics Biostatistics / Articles Posted by Francis Bursa / Page 3

About Francis Bursa

Senior Statistician – Francis joined Quantics in 2013. With a Masters from Cambridge and DPhil in Theoretical Physics from Oxford University, Francis brings high level mathematical ability and extensive experience in simulation techniques to Quantics. These techniques can be used to explore “what if” scenarios, reducing the need for further experimental data. Francis heads the R&D team.

Complications of fitting 4PL and 5PL models to bioassay data

We have previously discussed the 4 parameter logistic (4PL) model. Sometimes you may see slightly different versions of the 4PL equation – these are all mathematically equivalent. However,... read more →

4th April 2017
All Blogs, Bioassay

Reducing bioassay parallelism failures through better LOQ methodologies

Our recent paper, Estimation of Relative Potency from Bioassay Data that Include Values below the Limit of Quantitation (Francis Bursa, Kelly J. Fleetwood, Karie J. Hirst and Ann Yellowlees), discusses values... read more →

25th October 2016
All Blogs, Bioassay

Choosing a statistical model: Continuous response data

Previously, we discussed the definition of relative potency and how it relates to the concepts of biological similarity, and thus the need for parallelism between the reference dose response... read more →

24th August 2016
All Blogs, Bioassay

What is Relative Potency?

Relative potency (RP) refers to the dose of a test sample required to produce the same response in an assay as a dose of a reference sample. Since we... read more →

4th July 2016
All Blogs, Bioassay