In an ideal world, a single randomized controlled trial (RCT) would be used to compare and evaluate the individual treatment effects for all possible treatments of interest. Of course, this is often not feasible, in which case network meta-analysis (NMA) can be used to link RCTs with common treatment arms and compare treatments across different…
What do ISS & ISE mean? ISS & ISE stand for integrated summary of safety and integrated summary of effectiveness, respectively. These are not merely summaries, as the name might suggest, but rather documents comprised of integrated analyses of the safety and effectiveness of a study drug [1]. In other words, the results from all…
In our previous blog on survival analysis, we touched on some of the characteristics of survival data and various fundamental methods for analysing such data, focusing solely on non-parametric methods of analysis which only estimate the survival function at time points within the range of the raw data. I mentioned in the conclusion that parametric…
We have discussed Handling Missing Data in Clinical Trials elsewhere, and mentioned a kind of missing data known as ‘censoring’. In this blog we focus on techniques for dealing with this, known as ‘Survival Analysis’. Censoring occurs in time-to-event data (the time from a defined origin until the event of interest), when the event has…
In this post we examine the statistical software available for conducting Bayesian network meta-analyses (NMA). The first two sections provide some background information and a review of the available software – we hope this section will be of interest to all of our readers. The final section provides an introduction to conducting NMA in Stan…
Recently our team at Quantics were working on an analysis for an ecotoxicology client which called for us to use the Jonckheere-Terpstra test for ordered differences which is recommended by the OECD in their guidance document on statistical analysis of ecotoxicity data. We were subsequently asked to explain how it was used and we thought…