A key decision in the planning of a clinical trial is that of the sample size. As we’ve discussed previously, the number of participants in a trial is key... read more →
Blogs
In the first part of our series examining USP <1033> in depth, we discussed the goals of bioassay validation – specifically, to demonstrate that an assay is suitable for... read more →
During the early development of many therapeutic products, analytical and data management processes are often created quickly and pragmatically. Excel spreadsheets, macros, and bespoke code are widely used because... read more →
A key decision in the planning of a clinical trial is that of the sample size. As we’ve discussed previously, the number of participants in a trial is key... read more →
To perform any experiment, it is vital to ensure that enough data is collected. Too little data can not only mean imprecise results, but also makes distinguishing between reality... read more →
One key challenge when developing vaccines for human use is that it is often infeasible or unethical to assess the efficacy of the candidate vaccine directly in humans. As... read more →
In the first part of our series examining USP <1033> in depth, we discussed the goals of bioassay validation – specifically, to demonstrate that an assay is suitable for... read more →
During the early development of many therapeutic products, analytical and data management processes are often created quickly and pragmatically. Excel spreadsheets, macros, and bespoke code are widely used because... read more →
One can think of the life of a bioassay in two main acts. First comes the design and development of the assay, where the assay method is conceptualised, refined,... read more →
Population Pharmacokinetics (PopPK) is the gold standard method of understanding drug safety and efficacy, particularly as it provides a unique insight into the variation of drug behaviour from person... read more →
This is the third blog in our trilogy on techniques for population adjustment in network meta-analysis (NMA). Here we will focus on an approach called Multi-Level Network Meta-Regression (ML-NMR),... read more →
In this blog we will describe an alternative approach to indirect comparison - Simulated Treatment Comparison (STC) and discuss the key aspects to consider when looking to use the... read more →
If you’ve ever taken a rapid test for COVID-19, then you’ve used an in vitro diagnostic device (IVD). At the start of the pandemic, the only reliable method for... read more →
Unless you’ve been hiding under a rock for the past few months (and, honestly, who could blame you), you will have interacted with artificial intelligence (AI) in some form.... read more →
When James Lind (of Edinburgh, no less) first tested vitamin C as a cure for scurvy in 1747, he happened upon an experiment design which has persisted to this... read more →
The Organisation for Economic Co-operation and Development (OECD) is an inter-governmental organisation which aims to facilitate global trade and economic development. A key area is the development of global... read more →
In a previous blog, we looked at fitting dose-response models to quantal data in ecotoxicology scenarios. To recap, quantal data refers to data where the response variable takes a binary... read more →
Recently our team at Quantics were working on an analysis for an ecotoxicology client which called for us to use the Jonckheere-Terpstra test for ordered differences which is recommended... read more →