In previous blogs, we’ve examined the statistics behind Non-Compartmental PK/PD analysis. The existence of the Non-Compartmental Analysis (NCA) implies the existence of compartmental analysis, and, indeed, it is among the most commonly used methodologies for PK/PD statistics. Rather than extract results from data alone as in an NCA, a compartmental analysis involves fitting a model…
Crucial in understanding the safety and efficacy of a drug are how it percolates through the body, or pharmacokinetics (PK), and how the body responds to its presence, or pharmacodynamics (PD). As with any aspect of drug development, testing PK and PD requires collecting data, and, as with all data, interpreting that data requires statistics….
Population Pharmacokinetics (PopPK) is the gold standard method of understanding drug safety and efficacy, particularly as it provides a unique insight into the variation of drug behaviour from person to person. While not a novel methodology—Sheiner, Rosenberg and Marathe first demonstrated the analysis in 1977—techniques and approaches in PopPK have undergone continual improvement in the…