This method assumes that the assay results to be combined are independent and coming from a common distribution.
The assays are assumed to use the same design and the same laboratory procedures, so they can be assumed to be similarly variable and given equal weight.
Given Relative Potency results to combine, the estimate for the logarithm of the Combined Relative Potency is the mean of the logarithms of the Relative Potencies from the individual studies:
The logarithm of the 95% confidence interval is estimated as
where is the 97.5% quantile for the t-distribution with degrees of freedom.
