×
Menu
Index

Probit Model

 
 
and
 
 
where p is the probability of response at dose x, for the reference standard and the test sample respectively. 
 
φ is the cumulative distribution function for the standard normal distribution.
 
The ED50* is the dose where the probability of response is 0.5; log(ED50) = -A/B.
* Also known as midpoint, or EC50
 
is the slope of the relationship between p and log (x)at the ED50.
 
A is the intercept and B is commonly referred to as the slope coefficient.
 
 
For the parallel fit, B is the same for the two samples:
  and